The cedar berry tree has a long history in Native American medicine. Native Americans have used juniper to treat diabetes; such treatments by the Navajo, for example, are under clinical study; clinical studies have shown that treatment with juniper may retard the development of streptozotocin diabetes in mice. Native Americans also used juniper berries as a female contraceptive. The 17th Century herbalist physician Nicholas Culpeper recommended the ripened berries for conditions such as asthma and sciatica, as well as to speed childbirth.

Many parts of the tree are used in traditional medicine medicine due to its diuretic, antibiotic, germicidal, and antiseptic affects. Among the conditions that cedar berry has been used to treat are cough, fever, rheumatism, diabetes, tuberculosis, scurvy, toothache and to promote menstruation. Cedar berries have anti-viral and anti-fungal properties, stimulate the immune system, clean the lymph system, and can be used externally for warts.

While there has been little formal research done to substantiate the medical claims, a number of botanical databases note that the various chemical constituents of the leaves and cedar berries do have emetic, diuretic, antibiotic, germicidal and antiseptic properties. Dr. James Duke notes that the plant has chemicals that suggest it may help the body fight arthritis, asthma, cough, congestion, hepatitis and muscle stiffness.

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